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5WG8

Structure of PP5C with LB-100; 7-oxabicyclo[2.2.1]heptane-2,3-dicarbonyl moiety modeled in the density

Summary for 5WG8
Entry DOI10.2210/pdb5wg8/pdb
DescriptorSerine/threonine-protein phosphatase 5, MANGANESE (II) ION, (1S,2R,3S,4R)-3-(4-methylpiperazine-1-carbonyl)-7-oxabicyclo[2.2.1]heptane-2-carboxylic acid, ... (6 entities in total)
Functional Keywordshydrolase inhibitor, hydrolase, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
Biological sourceHomo sapiens (Human)
Total number of polymer chains1
Total formula weight38501.55
Authors
D'Arcy, B.M.,Swingle, M.R.,Honkanen, R.E.,Prakash, A. (deposition date: 2017-07-13, release date: 2018-07-18, Last modification date: 2023-10-04)
Primary citationD'Arcy, B.M.,Swingle, M.R.,Papke, C.M.,Abney, K.A.,Bouska, E.S.,Prakash, A.,Honkanen, R.E.
The Antitumor Drug LB-100 Is a Catalytic Inhibitor of Protein Phosphatase 2A (PPP2CA) and 5 (PPP5C) Coordinating with the Active-Site Catalytic Metals in PPP5C.
Mol. Cancer Ther., 18:556-566, 2019
Cited by
PubMed: 30679389
DOI: 10.1158/1535-7163.MCT-17-1143
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.65 Å)
Structure validation

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