5WG8
Structure of PP5C with LB-100; 7-oxabicyclo[2.2.1]heptane-2,3-dicarbonyl moiety modeled in the density
Summary for 5WG8
Entry DOI | 10.2210/pdb5wg8/pdb |
Descriptor | Serine/threonine-protein phosphatase 5, MANGANESE (II) ION, (1S,2R,3S,4R)-3-(4-methylpiperazine-1-carbonyl)-7-oxabicyclo[2.2.1]heptane-2-carboxylic acid, ... (6 entities in total) |
Functional Keywords | hydrolase inhibitor, hydrolase, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 1 |
Total formula weight | 38501.55 |
Authors | D'Arcy, B.M.,Swingle, M.R.,Honkanen, R.E.,Prakash, A. (deposition date: 2017-07-13, release date: 2018-07-18, Last modification date: 2023-10-04) |
Primary citation | D'Arcy, B.M.,Swingle, M.R.,Papke, C.M.,Abney, K.A.,Bouska, E.S.,Prakash, A.,Honkanen, R.E. The Antitumor Drug LB-100 Is a Catalytic Inhibitor of Protein Phosphatase 2A (PPP2CA) and 5 (PPP5C) Coordinating with the Active-Site Catalytic Metals in PPP5C. Mol. Cancer Ther., 18:556-566, 2019 Cited by PubMed: 30679389DOI: 10.1158/1535-7163.MCT-17-1143 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.65 Å) |
Structure validation
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