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5W4K

Crystal structure of the Thermus thermophilus 70S ribosome in complex with Klebsazolicin and bound to mRNA and A-, P- and E-site tRNAs at 2.7A resolution

This is a non-PDB format compatible entry.
Summary for 5W4K
Entry DOI10.2210/pdb5w4k/pdb
Related PRD IDPRD_002277
Descriptor23S Ribosomal RNA, 50S ribosomal protein L14, 50S ribosomal protein L15, ... (63 entities in total)
Functional Keywordsklebsazolicin, antibiotic, ripps, ribosome inhibitor, 70s ribosome, inhibition of translation, peptidyl transferase center, nascent peptide exit tunnel, ribosome-antibiotic complex, ribosome/antibiotic
Biological sourceEscherichia coli
More
Total number of polymer chains114
Total formula weight4576710.22
Authors
Primary citationMetelev, M.,Osterman, I.A.,Ghilarov, D.,Khabibullina, N.F.,Yakimov, A.,Shabalin, K.,Utkina, I.,Travin, D.Y.,Komarova, E.S.,Serebryakova, M.,Artamonova, T.,Khodorkovskii, M.,Konevega, A.L.,Sergiev, P.V.,Severinov, K.,Polikanov, Y.S.
Klebsazolicin inhibits 70S ribosome by obstructing the peptide exit tunnel.
Nat. Chem. Biol., 13:1129-1136, 2017
Cited by
PubMed: 28846667
DOI: 10.1038/nchembio.2462
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.7 Å)
Structure validation

217705

數據於2024-03-27公開中

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