5W1Y

SETD8 in complex with a covalent inhibitor

Summary for 5W1Y

• Entry DOI: 10.2210/pdb5w1y/pdb
• Descriptor: N-lysine methyltransferase KMT5A, 2-(4-methylpiperazin-1-yl)-3-(phenylsulfanyl)naphthalene-1,4-dione, UNKNOWN ATOM OR ION, ... (4 entities in total)
• Functional Keywords: structural genomics, structural genomics consortium, sgc, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• Biological source: Homo sapiens (Human)
• Cellular location: Nucleus: Q9NQR1
• Total number of polymer chains: 2
• Total formula weight: 38277.30

Authors

Tempel, W.,Yu, W.,Li, Y.,Blum, G.,Luo, M.,Pittella-Silva, F.,Bountra, C.,Arrowsmith, C.H.,Edwards, A.M.,Brown, P.J.,Structural Genomics Consortium (SGC) (deposition date: 2017-06-05, release date: 2017-06-21, Last modification date: 2023-10-04)

• Primary citation: Tempel, W.,Yu, W.,Li, Y.,Bountra, C.,Arrowsmith, C.H.,Edwards, A.M.,Brown, P.J.,Structural Genomics Consortium (SGC); SETD8 in complex with a covalent inhibitor; to be published,

Experimental method

X-RAY DIFFRACTION (1.7 Å)