5VXA

Structure of the human Mesh1-NADPH complex

Summary for 5VXA

• Entry DOI: 10.2210/pdb5vxa/pdb
• Descriptor: Guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase MESH1, ZINC ION, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ... (8 entities in total)
• Functional Keywords: mesh1 nadph, hydrolase
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 2
• Total formula weight: 43137.83

Authors

Rose, J.,Zhou, P. (deposition date: 2017-05-23, release date: 2018-05-23, Last modification date: 2022-03-30)

• Primary citation: Ding, C.C.,Rose, J.,Sun, T.,Wu, J.,Chen, P.H.,Lin, C.C.,Yang, W.H.,Chen, K.Y.,Lee, H.,Xu, E.,Tian, S.,Akinwuntan, J.,Zhao, J.,Guan, Z.,Zhou, P.,Chi, J.T.; MESH1 is a cytosolic NADPH phosphatase that regulates ferroptosis.; Nat Metab, 2:270-277, 2020; PubMed: 32462112; DOI: 10.1038/s42255-020-0181-1

Experimental method

X-RAY DIFFRACTION (2.1 Å)