5VX2

Mcl-1 in complex with Bim-h3Pc-RT

Summary for 5VX2

Entry DOI	10.2210/pdb5vx2/pdb
Descriptor	Induced myeloid leukemia cell differentiation protein Mcl-1 homolog,Induced myeloid leukemia cell differentiation protein Mcl-1 chimera, Bcl-2-like protein 11, 1,2-ETHANEDIOL, ... (4 entities in total)
Functional Keywords	apoptosis, bcl-2 family, pro-surivial
Biological source	Mus musculus (Mouse) More
Total number of polymer chains	4
Total formula weight	43124.67
Authors	Cowan, A.D.,Brouwer, J.M.,Colman, P.M.,Czabotar, P.E. (deposition date: 2017-05-23, release date: 2017-11-15, Last modification date: 2020-01-08)
Primary citation	Brouwer, J.M.,Lan, P.,Cowan, A.D.,Bernardini, J.P.,Birkinshaw, R.W.,van Delft, M.F.,Sleebs, B.E.,Robin, A.Y.,Wardak, A.,Tan, I.K.,Reljic, B.,Lee, E.F.,Fairlie, W.D.,Call, M.J.,Smith, B.J.,Dewson, G.,Lessene, G.,Colman, P.M.,Czabotar, P.E. Conversion of Bim-BH3 from Activator to Inhibitor of Bak through Structure-Based Design. Mol. Cell, 68:659-672.e9, 2017 Cited by PubMed: 29149594 DOI: 10.1016/j.molcel.2017.11.001 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.851 Å)

Structure validation