5VSE

Structure of human G9a SET-domain (EHMT2) in complex with inhibitor 17: N~2~-cyclopentyl-6,7-dimethoxy-N~2~-methyl-N~4~-(1-methylpiperidin-4-yl)quinazoline-2,4-diamine

Summary for 5VSE

• Entry DOI: 10.2210/pdb5vse/pdb
• Descriptor: Histone-lysine N-methyltransferase EHMT2, ZINC ION, S-ADENOSYLMETHIONINE, ... (5 entities in total)
• Functional Keywords: protein-small molecule inhibitor complex, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 2
• Total formula weight: 65561.07

Authors

Babault, N.,Xiong, Y.,Liu, J.,Jin, J. (deposition date: 2017-05-11, release date: 2017-07-19, Last modification date: 2023-10-04)

• Primary citation: Xiong, Y.,Li, F.,Babault, N.,Wu, H.,Dong, A.,Zeng, H.,Chen, X.,Arrowsmith, C.H.,Brown, P.J.,Liu, J.,Vedadi, M.,Jin, J.; Structure-activity relationship studies of G9a-like protein (GLP) inhibitors.; Bioorg. Med. Chem., 25:4414-4423, 2017; PubMed: 28662962; DOI: 10.1016/j.bmc.2017.06.021

Experimental method

X-RAY DIFFRACTION (1.6 Å)