5VHB

Crystal structure of Protein Kinase A in complex with the PKI peptide and Aminobenzothiazole based inhibitor

Summary for 5VHB

• Entry DOI: 10.2210/pdb5vhb/pdb
• Related: 5VI9 5VIB
• Descriptor: cAMP-dependent protein kinase catalytic subunit alpha, PKI peptide, N-[(2S)-1-hydroxy-3-phenylpropan-2-yl]-4-(pyridin-4-yl)benzamide, ... (4 entities in total)
• Functional Keywords: kinase, transferase
• Biological source: Bos taurus (Bovine); More
• Cellular location: Cytoplasm : P00517
• Total number of polymer chains: 2
• Total formula weight: 43223.16

Authors

Judge, R.A. (deposition date: 2017-04-12, release date: 2018-01-31, Last modification date: 2018-04-04)

• Primary citation: Judge, R.A.,Vasudevan, A.,Scott, V.E.,Simler, G.H.,Pratt, S.D.,Namovic, M.T.,Putman, C.B.,Aguirre, A.,Stoll, V.S.,Mamo, M.,Swann, S.I.,Cassar, S.C.,Faltynek, C.R.,Kage, K.L.,Boyce-Rustay, J.M.,Hobson, A.D.; Design of Aminobenzothiazole Inhibitors of Rho Kinases 1 and 2 by Using Protein Kinase A as a Structure Surrogate.; Chembiochem, 19:613-621, 2018; PubMed: 29314498; DOI: 10.1002/cbic.201700547

Experimental method

X-RAY DIFFRACTION (1.61 Å)