5VAD
Crystal structure of human Prolyl-tRNA synthetase (PRS) in complex with inhibitor
Summary for 5VAD
| Entry DOI | 10.2210/pdb5vad/pdb |
| Descriptor | Bifunctional glutamate/proline--tRNA ligase, 3-[(cyclohexanecarbonyl)amino]-N-(2,3-dihydro-1H-inden-2-yl)pyrazine-2-carboxamide, PROLINE, ... (5 entities in total) |
| Functional Keywords | aminoacyl-trna synthetase, atp dependent, inhibitor, ligase-ligase inhibitor complex, ligase/ligase inhibitor |
| Biological source | Homo sapiens (Human) |
| Cellular location | Cytoplasm : P07814 |
| Total number of polymer chains | 2 |
| Total formula weight | 117901.27 |
| Authors | Okada, K.,Skene, R.J. (deposition date: 2017-03-24, release date: 2017-05-31, Last modification date: 2017-06-07) |
| Primary citation | Adachi, R.,Okada, K.,Skene, R.,Ogawa, K.,Miwa, M.,Tsuchinaga, K.,Ohkubo, S.,Henta, T.,Kawamoto, T. Discovery of a novel prolyl-tRNA synthetase inhibitor and elucidation of its binding mode to the ATP site in complex with l-proline. Biochem. Biophys. Res. Commun., 488:393-399, 2017 Cited by PubMed: 28501621DOI: 10.1016/j.bbrc.2017.05.064 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (2.36 Å) |
Structure validation
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