6W4M

CRYSTAL STRUCTURE OF THE ADCC-POTENT, WEAKLY NEUTRALIZING HIV ENV CO-RECEPTOR BINDING SITE ANTIBODY N12-I2 FAB IN COMPLEX WITH HIV-1 CLADE A/E GP120 AND M48U1

Replaces:  5UWE

Summary for 6W4M

• Entry DOI: 10.2210/pdb6w4m/pdb
• Descriptor: clade A/E 93TH057 HIV-1 gp120 core, ANTI-HIV ANTIBODY N12-I2 FAB LIGHT CHAIN, ANTI-HIV ANTIBODY N12-I2 FAB HEAVY CHAIN, ... (5 entities in total)
• Functional Keywords: adcc and neutralizing anti-hiv-1 env antibody n12-i2, cd4i antibody, fab fragment, hiv-1 gp120, immune system, clade a/e 93th057, viral protein-immune system complex, viral protein/immune system
• Biological source: Human immunodeficiency virus 1; More
• Total number of polymer chains: 4
• Total formula weight: 93456.73

Authors

Tolbert, W.D.,Gohain, N.,Pazgier, M. (deposition date: 2020-03-11, release date: 2020-08-05, Last modification date: 2023-11-15)

• Primary citation: Tolbert, W.D.,Sherburn, R.,Gohain, N.,Ding, S.,Flinko, R.,Orlandi, C.,Ray, K.,Finzi, A.,Lewis, G.K.,Pazgier, M.; Defining rules governing recognition and Fc-mediated effector functions to the HIV-1 co-receptor binding site.; Bmc Biol., 18:91-91, 2020; PubMed: 32693837; DOI: 10.1186/s12915-020-00819-y

Experimental method

X-RAY DIFFRACTION (3.2 Å)