5UOQ

CRYSTAL STRUCTURE OF THE PROTOTYPE FOAMY VIRUS INTASOME WITH A 2- PYRIDINONE AMINAL INHIBITOR (COMPOUND 31)

Summary for 5UOQ

• Entry DOI: 10.2210/pdb5uoq/pdb
• Related: 5uop
• Descriptor: INTEGRASE, NUCLEOTIDE PREPROCESSED PFV DONOR DNA (NON-TRANSFERRED STRAND), NUCLEOTIDE PREPROCESSED PFV DONOR DNA (TRANSFERRED STRAND), ... (9 entities in total)
• Functional Keywords: transferase-dna complex, dna integration, viral protein, recombination-inhibitor-dna complex, transferase-dna-inhibitor complex, transferase/dna/inhibitor
• Biological source: Human spumaretrovirus (SFVcpz(hu)); More
• Cellular location: Integrase: Virion . Protease/Reverse transcriptase/ribonuclease H: Host nucleus : P14350
• Total number of polymer chains: 4
• Total formula weight: 101335.46

Authors

Klein, D.J. (deposition date: 2017-02-01, release date: 2017-03-29, Last modification date: 2024-03-06)

• Primary citation: Schreier, J.D.,Embrey, M.W.,Raheem, I.T.,Barbe, G.,Campeau, L.C.,Dubost, D.,McCabe Dunn, J.,Grobler, J.,Hartingh, T.J.,Hazuda, D.J.,Klein, D.,Miller, M.D.,Moore, K.P.,Nguyen, N.,Pajkovic, N.,Powell, D.A.,Rada, V.,Sanders, J.M.,Sisko, J.,Steele, T.G.,Wai, J.,Walji, A.,Xu, M.,Coleman, P.J.; Discovery and optimization of 2-pyridinone aminal integrase strand transfer inhibitors for the treatment of HIV.; Bioorg. Med. Chem. Lett., 27:2038-2046, 2017; PubMed: 28285916; DOI: 10.1016/j.bmcl.2017.02.039

Experimental method

X-RAY DIFFRACTION (2.61 Å)