5U2N

Crystal structure of human NAMPT with A-1326133

Summary for 5U2N

• Entry DOI: 10.2210/pdb5u2n/pdb
• Related: 5U2M
• Descriptor: Nicotinamide phosphoribosyltransferase, SULFATE ION, N-{4-[1-(2-methylpropanoyl)piperidin-4-yl]phenyl}-2H-pyrrolo[3,4-c]pyridine-2-carboxamide, ... (4 entities in total)
• Functional Keywords: nampt inhibitor, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• Biological source: Homo sapiens (Human)
• Cellular location: Nucleus : P43490
• Total number of polymer chains: 2
• Total formula weight: 109598.04

Authors

Longenecker, K.L.,Raich, D.,Korepanova, A.V. (deposition date: 2016-11-30, release date: 2017-06-28, Last modification date: 2023-10-04)

• Primary citation: Wilsbacher, J.L.,Cheng, M.,Cheng, D.,Trammell, S.A.J.,Shi, Y.,Guo, J.,Koeniger, S.L.,Kovar, P.J.,He, Y.,Selvaraju, S.,Heyman, H.R.,Sorensen, B.K.,Clark, R.F.,Hansen, T.M.,Longenecker, K.L.,Raich, D.,Korepanova, A.V.,Cepa, S.,Towne, D.L.,Abraham, V.C.,Tang, H.,Richardson, P.L.,McLoughlin, S.M.,Badagnani, I.,Curtin, M.L.,Michaelides, M.R.,Maag, D.,Buchanan, F.G.,Chiang, G.G.,Gao, W.,Rosenberg, S.H.,Brenner, C.,Tse, C.; Discovery and Characterization of Novel Nonsubstrate and Substrate NAMPT Inhibitors.; Mol. Cancer Ther., 16:1236-1245, 2017; PubMed: 28468779; DOI: 10.1158/1535-7163.MCT-16-0819

Experimental method

X-RAY DIFFRACTION (1.73 Å)