Binary complex crystal structure of DNA Polymerase Beta with G:T mismatch at the primer terminus

Replaces:  5J0V

Summary for 5TZV

DescriptorDNA polymerase beta, DNA (5'-D(*CP*CP*GP*AP*CP*AP*GP*CP*GP*CP*AP*TP*CP*AP*GP*C)-3'), DNA (5'-D(*GP*CP*TP*GP*AP*TP*GP*CP*GP*T)-3'), ... (6 entities in total)
Functional Keywordsdna polymerase, fidelity, mismatch extension, transferase-dna complex, transferase/dna
Biological sourceHomo sapiens (Human)
Cellular locationNucleus P06746
Total number of polymer chains4
Total molecular weight47798.84
Wilson, S.H.,Batra, V.K. (deposition date: 2016-11-22, release date: 2016-12-07)
Primary citation
Batra, V.K.,Beard, W.A.,Pedersen, L.C.,Wilson, S.H.
Structures of DNA Polymerase Mispaired DNA Termini Transitioning to Pre-catalytic Complexes Support an Induced-Fit Fidelity Mechanism.
Structure, 24:1863-1875, 2016
PubMed: 27642161 (PDB entries with the same primary citation)
DOI: 10.1016/j.str.2016.08.006
MImport into Mendeley
Experimental method

Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.229300.7%4.2%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
Download full validation report