5TX2

Miniature TGF-beta2 3-mutant monomer

Summary for 5TX2

• Entry DOI: 10.2210/pdb5tx2/pdb
• Related: 5TX4 5TX6
• Descriptor: Transforming growth factor beta-2 (2 entities in total)
• Functional Keywords: growth factor, cytokine
• Biological source: Mus musculus (Mouse)
• Cellular location: Secreted: P27090
• Total number of polymer chains: 2
• Total formula weight: 21206.58

Authors

Taylor, A.B.,Kim, S.K.,Hart, P.J.,Hinck, A.P. (deposition date: 2016-11-15, release date: 2017-03-01, Last modification date: 2023-10-04)

• Primary citation: Kim, S.K.,Barron, L.,Hinck, C.S.,Petrunak, E.M.,Cano, K.E.,Thangirala, A.,Iskra, B.,Brothers, M.,Vonberg, M.,Leal, B.,Richter, B.,Kodali, R.,Taylor, A.B.,Du, S.,Barnes, C.O.,Sulea, T.,Calero, G.,Hart, P.J.,Hart, M.J.,Demeler, B.,Hinck, A.P.; An engineered transforming growth factor beta (TGF-beta ) monomer that functions as a dominant negative to block TGF-beta signaling.; J. Biol. Chem., 292:7173-7188, 2017; PubMed: 28228478; DOI: 10.1074/jbc.M116.768754

Experimental method

X-RAY DIFFRACTION (1.82 Å)