5TVN

Crystal structure of the LSD-bound 5-HT2B receptor

Summary for 5TVN

Entry DOI	10.2210/pdb5tvn/pdb
Descriptor	Chimera protein of human 5-hydroxytryptamine receptor 2B and E. Coli soluble cytochrome b562, (8alpha)-N,N-diethyl-6-methyl-9,10-didehydroergoline-8-carboxamide, CHOLESTEROL, ... (7 entities in total)
Functional Keywords	lsd, gpcr, serotonin receptor, membrane protein
Biological source	Homo sapiens (Human) More
Total number of polymer chains	1
Total formula weight	46500.73
Authors	Wacker, D.,Wang, S.,McCorvy, J.D.,Betz, R.M.,Venkatakrishnan, A.J.,Levit, A.,Lansu, K.,Schools, Z.L.,Che, T.,Nichols, D.E.,Shoichet, B.K.,Dror, R.O.,Roth, B.L. (deposition date: 2016-11-09, release date: 2017-02-01, Last modification date: 2023-10-18)
Primary citation	Wacker, D.,Wang, S.,McCorvy, J.D.,Betz, R.M.,Venkatakrishnan, A.J.,Levit, A.,Lansu, K.,Schools, Z.L.,Che, T.,Nichols, D.E.,Shoichet, B.K.,Dror, R.O.,Roth, B.L. Crystal Structure of an LSD-Bound Human Serotonin Receptor. Cell, 168:377-389.e12, 2017 Cited by PubMed: 28129538 DOI: 10.1016/j.cell.2016.12.033 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.9 Å)

Structure validation