5TUR

Pim-1 kinase in complex with a 7-azaindole

Summary for 5TUR

Entry DOI	10.2210/pdb5tur/pdb
Descriptor	Serine/threonine-protein kinase pim-1, 1-methyl-2-[4-(piperazin-1-yl)phenyl]-1H-pyrrolo[2,3-b]pyridine-4-carbonitrile (3 entities in total)
Functional Keywords	kinase, inhibitor, transferase-transferase inhibitor complex, transferase/transferase inhibitor
Biological source	Homo sapiens (Human)
Cellular location	Isoform 2: Cytoplasm. Isoform 1: Cell membrane: P11309
Total number of polymer chains	1
Total formula weight	45796.72
Authors	Mechin, I.,Zhang, Y.,Wang, R.,Batchelor, J.D.,Mclean, L. (deposition date: 2016-11-07, release date: 2017-10-11, Last modification date: 2024-03-06)
Primary citation	Barberis, C.,Moorcroft, N.,Arendt, C.,Levit, M.,Moreno-Mazza, S.,Batchelor, J.,Mechin, I.,Majid, T. Discovery of N-substituted 7-azaindoles as PIM1 kinase inhibitors - Part I. Bioorg. Med. Chem. Lett., 27:4730-4734, 2017 Cited by PubMed: 28947155 DOI: 10.1016/j.bmcl.2017.08.069 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.948 Å)

Structure validation