5TOZ

JAK3 with covalent inhibitor PF-06651600

Summary for 5TOZ

• Entry DOI: 10.2210/pdb5toz/pdb
• Descriptor: Tyrosine-protein kinase JAK3, 1-{(2S,5R)-2-methyl-5-[(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino]piperidin-1-yl}propan-1-one, SULFATE ION, ... (4 entities in total)
• Functional Keywords: jak3 covalent kinase, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• Biological source: Homo sapiens (Human)
• Cellular location: Endomembrane system ; Peripheral membrane protein : P52333
• Total number of polymer chains: 1
• Total formula weight: 36927.08

Authors

Vajdos, F.F. (deposition date: 2016-10-19, release date: 2016-11-09, Last modification date: 2017-11-22)

• Primary citation: Telliez, J.B.,Dowty, M.E.,Wang, L.,Jussif, J.,Lin, T.,Li, L.,Moy, E.,Balbo, P.,Li, W.,Zhao, Y.,Crouse, K.,Dickinson, C.,Symanowicz, P.,Hegen, M.,Banker, M.E.,Vincent, F.,Unwalla, R.,Liang, S.,Gilbert, A.M.,Brown, M.F.,Hayward, M.,Montgomery, J.,Yang, X.,Bauman, J.,Trujillo, J.I.,Casimiro-Garcia, A.,Vajdos, F.F.,Leung, L.,Geoghegan, K.F.,Quazi, A.,Xuan, D.,Jones, L.,Hett, E.,Wright, K.,Clark, J.D.,Thorarensen, A.; Discovery of a JAK3-Selective Inhibitor: Functional Differentiation of JAK3-Selective Inhibition over pan-JAK or JAK1-Selective Inhibition.; ACS Chem. Biol., 11:3442-3451, 2016; PubMed: 27791347; DOI: 10.1021/acschembio.6b00677

Experimental method

X-RAY DIFFRACTION (1.98 Å)