Structure of the TPR oligomerization domain

Summary for 5TO5

Related5TO6 5TO7
DescriptorNucleoprotein TPR (2 entities in total)
Functional Keywordstpr oligomerization domain, receptor tyrosine kinase, met, oncogenic fusion kinases, cell cycle
Biological sourceHomo sapiens (Human)
Total number of polymer chains2
Total molecular weight33495.84
Pal, K.,Xu, Q.,Zhou, X.E.,Melcher, K.,Xu, H.E. (deposition date: 2016-10-16, release date: 2017-10-18, Last modification date: 2019-05-01)
Primary citation
Pal, K.,Bandyopadhyay, A.,Zhou, X.E.,Xu, Q.,Marciano, D.P.,Brunzelle, J.S.,Yerrum, S.,Griffin, P.R.,Vande Woude, G.,Melcher, K.,Xu, H.E.
Structural Basis of TPR-Mediated Oligomerization and Activation of Oncogenic Fusion Kinases.
Structure, 25:867-877.e3, 2017
PubMed: 28528776 (PDB entries with the same primary citation)
DOI: 10.1016/j.str.2017.04.015
MImport into Mendeley
Experimental method

Structure validation

RfreeClashscoreRamachandran outliersSidechain outliers 0.28650 0.4%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution

More Asymmetric unit images

Molmil generated image of 5to5
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Molmil generated image of 5to5
rotated about x axis by 90°
Molmil generated image of 5to5
rotated about y axis by 90°