5TIW

Schistosoma haematobium (Blood Fluke) Sulfotransferase/Racemic Oxamniquine Complex

Summary for 5TIW

• Entry DOI: 10.2210/pdb5tiw/pdb
• Related: 5TIV 5TIX 5TIY 5TIZ
• Descriptor: Sulfotransferase, ADENOSINE-3'-5'-DIPHOSPHATE, {(2S)-7-nitro-2-[(propan-2-ylamino)methyl]-1,2,3,4-tetrahydroquinolin-6-yl}methanol, ... (7 entities in total)
• Functional Keywords: sulfotransferase, parasite, helminth, oxamniquine, transferase
• Biological source: Schistosoma haematobium (Blood fluke)
• Total number of polymer chains: 2
• Total formula weight: 60451.93

Authors

Taylor, A.B.,Hart, P.J. (deposition date: 2016-10-03, release date: 2017-05-31, Last modification date: 2023-10-04)

• Primary citation: Taylor, A.B.,Roberts, K.M.,Cao, X.,Clark, N.E.,Holloway, S.P.,Donati, E.,Polcaro, C.M.,Pica-Mattoccia, L.,Tarpley, R.S.,McHardy, S.F.,Cioli, D.,LoVerde, P.T.,Fitzpatrick, P.F.,Hart, P.J.; Structural and enzymatic insights into species-specific resistance to schistosome parasite drug therapy.; J. Biol. Chem., 292:11154-11164, 2017; PubMed: 28536265; DOI: 10.1074/jbc.M116.766527

Experimental method

X-RAY DIFFRACTION (1.66 Å)