5TF8

Nucleotide-binding domain 1 of the human cystic fibrosis transmembrane conductance regulator (CFTR) with dTTP

Summary for 5TF8

• Entry DOI: 10.2210/pdb5tf8/pdb
• Related: 5TF7 5TFA 5TFB 5TFC 5TFD 5TFE 5TFF 5TFG 5TFH 5TFI 5TFJ 5TGK
• Descriptor: Cystic fibrosis transmembrane conductance regulator, THYMIDINE-5'-TRIPHOSPHATE, MAGNESIUM ION, ... (4 entities in total)
• Functional Keywords: hnbd1, cftr, abc transport, atp, hydrolase
• Biological source: Homo sapiens (Human)
• Cellular location: Apical cell membrane ; Multi-pass membrane protein {ECO:0000269|Ref: P13569
• Total number of polymer chains: 1
• Total formula weight: 26031.88

Authors

Wang, C.,Aleksandrov, A.A.,Yang, Z.,Forouhar, F.,Proctor, E.,Kota, P.,An, J.,Kaplan, A.,Khazanov, N.,Boel, G.,Stockwell, B.R.,Senderowitz, H.,Dokholyan, N.V.,Riordan, J.R.,Brouillette, C.G.,Hunt, J.F. (deposition date: 2016-09-24, release date: 2018-05-09, Last modification date: 2023-10-04)

• Primary citation: Wang, C.,Aleksandrov, A.A.,Yang, Z.,Forouhar, F.,Proctor, E.,Kota, P.,An, J.,Kaplan, A.,Khazanov, N.,Boel, G.,Stockwell, B.R.,Senderowitz, H.,Dokholyan, N.V.,Riordan, J.R.,Brouillette, C.G.,Hunt, J.F.; Thermodynamic correction of F508del-CFTR by ligand binding to a remote site in the mutated domain; To Be Published,

Experimental method

X-RAY DIFFRACTION (1.861 Å)