5TBW

Crystal structure of chlorolissoclimide bound to the yeast 80S ribosome

This is a non-PDB format compatible entry.

Summary for 5TBW

• Entry DOI: 10.2210/pdb5tbw/pdb
• Descriptor: 25S ribosomal RNA, 60S ribosomal protein L8-A, 60S ribosomal protein L9-A, ... (87 entities in total)
• Functional Keywords: protein translation inhibitor, complex, ribosome
• Biological source: Saccharomyces cerevisiae (strain ATCC 204508 / S288c); More
• Total number of polymer chains: 159
• Total formula weight: 6294772.15

Authors

Konst, Z.A.,Szklarski, A.R.,Pellegrino, S.,Michalak, S.E.,Meyer, M.,Zanette, C.,Cencic, R.,Nam, S.,Horne, D.A.,Pelletier, J.,Mobley, D.L.,Yusupova, G.,Yusupov, M.,Vanderwal, C.D. (deposition date: 2016-09-13, release date: 2017-07-26, Last modification date: 2024-01-17)

• Primary citation: Konst, Z.A.,Szklarski, A.R.,Pellegrino, S.,Michalak, S.E.,Meyer, M.,Zanette, C.,Cencic, R.,Nam, S.,Voora, V.K.,Horne, D.A.,Pelletier, J.,Mobley, D.L.,Yusupova, G.,Yusupov, M.,Vanderwal, C.D.; Synthesis facilitates an understanding of the structural basis for translation inhibition by the lissoclimides.; Nat Chem, 9:1140-1149, 2017; PubMed: 29064494; DOI: 10.1038/nchem.2800

Experimental method

X-RAY DIFFRACTION (3 Å)