5T8J

Synthesis and biological evaluation of novel selective androgen receptor modulators (SARMs). Part II: Optimization of 4-(pyrrolidin-1-yl)benzonitrile derivatives

Summary for 5T8J

• Entry DOI: 10.2210/pdb5t8j/pdb
• Related: 5T8E
• Descriptor: Androgen receptor, GLYCEROL, 2-fluoro-4-[(2S,3S)-3-hydroxy-2,3-dimethylpyrrolidin-1-yl]-3-methylbenzonitrile, ... (4 entities in total)
• Functional Keywords: androgen receptor, selective androgen receptor modulators, sarms, hormone receptor
• Biological source: Homo sapiens (Human)
• Cellular location: Nucleus : P10275
• Total number of polymer chains: 1
• Total formula weight: 30490.66

Authors

Wilson, K.P. (deposition date: 2016-09-07, release date: 2017-04-26)

• Primary citation: Asano, M.,Hitaka, T.,Imada, T.,Yamada, M.,Morimoto, M.,Shinohara, H.,Hara, T.,Yamaoka, M.,Santou, T.,Nakayama, M.,Imai, Y.,Habuka, N.,Yano, J.,Wilson, K.,Fujita, H.,Hasuoka, A.; Synthesis and biological evaluation of novel selective androgen receptor modulators (SARMs). Part II: Optimization of 4-(pyrrolidin-1-yl)benzonitrile derivatives.; Bioorg. Med. Chem. Lett., 27:1897-1901, 2017; PubMed: 28363748; DOI: 10.1016/j.bmcl.2017.03.038

Experimental method

X-RAY DIFFRACTION (2.7 Å)