5T4H

Human DPP4 in complex with ligand 34n

Summary for 5T4H

• Entry DOI: 10.2210/pdb5t4h/pdb
• Related: 5T4B 5T4E 5T4F
• Descriptor: Dipeptidyl peptidase 4, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... (6 entities in total)
• Functional Keywords: structure-based drug design, diabetes, dpp4 inhibitors, hydrolase, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 2
• Total formula weight: 173934.13

Authors

Scapin, G. (deposition date: 2016-08-29, release date: 2016-10-05, Last modification date: 2023-10-04)

• Primary citation: Pissarnitski, D.A.,Zhao, Z.,Cole, D.,Wu, W.L.,Domalski, M.,Clader, J.W.,Scapin, G.,Voigt, J.,Soriano, A.,Kelly, T.,Powles, M.A.,Yao, Z.,Burnett, D.A.; Scaffold-hopping from xanthines to tricyclic guanines: A case study of dipeptidyl peptidase 4 (DPP4) inhibitors.; Bioorg.Med.Chem., 24:5534-5545, 2016; PubMed: 27670099; DOI: 10.1016/j.bmc.2016.09.007

Experimental method

X-RAY DIFFRACTION (2.61 Å)