5P9F

BTK IN COMPLEX WITH GDC-0834

Summary for 5P9F

• Entry DOI: 10.2210/pdb5p9f/pdb
• Group deposition: Crystal structures of Tyrosine-protein kinase BTK in complex with inhibitors (G_1002011)
• Descriptor: Tyrosine-protein kinase BTK, N-{3-[6-({4-[(2R)-1,4-dimethyl-3-oxopiperazin-2-yl]phenyl}amino)-4-methyl-5-oxo-4,5-dihydropyrazin-2-yl]-2-methylphenyl }-4,5,6,7-tetrahydro-1-benzothiophene-2-carboxamide, 1,2-ETHANEDIOL, ... (5 entities in total)
• Functional Keywords: lead optimization, protein kinase, transferase
• Biological source: Homo sapiens (Human)
• Cellular location: Cytoplasm: Q06187
• Total number of polymer chains: 1
• Total formula weight: 33263.18

Authors

Gardberg, A.S. (deposition date: 2016-09-20, release date: 2017-05-24, Last modification date: 2021-11-17)

• Primary citation: Bender, A.T.,Gardberg, A.,Pereira, A.,Johnson, T.,Wu, Y.,Grenningloh, R.,Head, J.,Morandi, F.,Haselmayer, P.,Liu-Bujalski, L.; Ability of Bruton's Tyrosine Kinase Inhibitors to Sequester Y551 and Prevent Phosphorylation Determines Potency for Inhibition of Fc Receptor but not B-Cell Receptor Signaling.; Mol. Pharmacol., 91:208-219, 2017; PubMed: 28062735; DOI: 10.1124/mol.116.107037

Experimental method

X-RAY DIFFRACTION (1.71 Å)