5OMG

p38alpha in complex with pyrazolobenzothiazine inhibitor COXP4M12

Summary for 5OMG

Entry DOI	10.2210/pdb5omg/pdb
Descriptor	Mitogen-activated protein kinase 14, octyl beta-D-glucopyranoside, 3-(4-fluorophenyl)-4-methyl-1~{H}-pyrazolo[4,3-c][1,2]benzothiazine 5,5-dioxide, ... (4 entities in total)
Functional Keywords	p38, kinase, inhibitor, pyrazolobenzothiazine, complex, transferase
Biological source	Homo sapiens (Human)
Total number of polymer chains	1
Total formula weight	41964.91
Authors	Buehrmann, M.,Rauh, D. (deposition date: 2017-07-31, release date: 2019-03-13, Last modification date: 2020-07-29)
Primary citation	Bartolini, D.,Buhrmann, M.,Barreca, M.L.,Manfroni, G.,Cecchetti, V.,Rauh, D.,Galli, F. Co-crystal structure determination and cellular evaluation of 1,4-dihydropyrazolo[4,3-c] [1,2] benzothiazine 5,5-dioxide p38 alpha MAPK inhibitors. Biochem.Biophys.Res.Commun., 511:579-586, 2019 Cited by PubMed: 30824186 DOI: 10.1016/j.bbrc.2019.02.063 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2 Å)

Structure validation