5OF9

Crystal structure of human MORC2 (residues 1-603)

Summary for 5OF9

Entry DOI	10.2210/pdb5of9/pdb
Descriptor	MORC family CW-type zinc finger protein 2, ZINC ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, ... (5 entities in total)
Functional Keywords	ghkl atpase, chromatin remodeler, epigenetic silencing, transcriptional repressor, coiled-coil, cw domain, dna binding protein, charcot-marie-tooth disease, spinal muscular atrophy, nuclear protein
Biological source	Homo sapiens (Human)
Cellular location	Nucleus : Q9Y6X9
Total number of polymer chains	2
Total formula weight	141229.82
Authors	Douse, C.H.,Shamin, M.,Modis, Y. (deposition date: 2017-07-10, release date: 2018-02-14, Last modification date: 2024-01-17)
Primary citation	Douse, C.H.,Bloor, S.,Liu, Y.,Shamin, M.,Tchasovnikarova, I.A.,Timms, R.T.,Lehner, P.J.,Modis, Y. Neuropathic MORC2 mutations perturb GHKL ATPase dimerization dynamics and epigenetic silencing by multiple structural mechanisms. Nat Commun, 9:651-651, 2018 Cited by PubMed: 29440755 DOI: 10.1038/s41467-018-03045-x PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.807 Å)

Structure validation