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5O5M

Crystal Structure of the Protein-Kinase A catalytic subunit from Criteculus Griseus in complex with compounds RKp120 and RKp117

Summary for 5O5M
Entry DOI10.2210/pdb5o5m/pdb
DescriptorcAMP-dependent protein kinase catalytic subunit alpha, RKp120, [2-[(4-isoquinolin-5-ylsulfonyl-1,4-diazepan-1-yl)methyl]phenyl]boronic acid, ... (5 entities in total)
Functional Keywordscomplex, peptidic ligand, transferase
Biological sourceCricetulus griseus (Chinese hamster)
More
Total number of polymer chains2
Total formula weight43600.66
Authors
Mueller, J.M.,Heine, A.,Klebe, G. (deposition date: 2017-06-02, release date: 2018-06-13, Last modification date: 2019-05-15)
Primary citationMueller, J.M.,Kirschner, R.,Geyer, A.,Klebe, G.
Conceptional Design of Self-Assembling Bisubstrate-like Inhibitors of Protein Kinase A Resulting in a Boronic Acid Glutamate Linkage
Acs Omega, 2019
Cited by
DOI: 10.1021/acsomega.8b02364
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.583 Å)
Structure validation

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