5O5F

Crystal structure of the human BRPF1 bromodomain in complex with BZ038

Summary for 5O5F

Entry DOI	10.2210/pdb5o5f/pdb
Descriptor	Peregrin, 1-ethyl-~{N}-[(~{R})-(3-fluorophenyl)-(1-methylimidazol-2-yl)methyl]-2,3-bis(oxidanylidene)-4~{H}-quinoxaline-6-carboxamide, NITRATE ION, ... (4 entities in total)
Functional Keywords	bromodomain and phd finger-containing protein 1(brpf1), monocytic leukemia zinc-finger (moz), inhibitor, transcription, dna binding protein
Biological source	Homo sapiens (Human)
Total number of polymer chains	1
Total formula weight	14249.13
Authors	Zhu, J.,Caflisch, A. (deposition date: 2017-06-01, release date: 2018-06-13, Last modification date: 2024-01-17)
Primary citation	Zhu, J.,Zhou, C.,Caflisch, A. Structure-based discovery of selective BRPF1 bromodomain inhibitors. Eur J Med Chem, 155:337-352, 2018 Cited by PubMed: 29902720 DOI: 10.1016/j.ejmech.2018.05.037 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.302 Å)

Structure validation