5NRF

Crystal structure of human chitotriosidase-1 (hCHIT) catalytic domain in complex with compound 7i

5NRF の概要

• エントリーDOI: 10.2210/pdb5nrf/pdb
• 分子名称: Chitotriosidase-1, 1-(3-azanyl-1~{H}-1,2,4-triazol-5-yl)-~{N}-[2-(4-chlorophenyl)ethyl]-~{N}-(phenylmethyl)piperidin-4-amine, GLYCEROL, ... (4 entities in total)
• 機能のキーワード: chitotriosidase-1 (hchit) catalytic domain in complex with compound 7i, hydrolase
• 由来する生物種: Homo sapiens (Human)
• 細胞内の位置: Secreted: Q13231
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 42727.33

構造登録者

Mazur, M.,Olczak, J.,Olejniczak, S.,Koralewski, R.,Czestkowski, W.,Jedrzejczak, A.,Golab, J.,Dzwonek, K.,Dymek, B.,Sklepkiewicz, P.,Zagozdzon, A.,Noonan, T.,Mahboubi, K.,Conway, B.,Sheeler, R.,Beckett, P.,Hungerford, W.M.,Podjarny, A.,Mitschler, A.,Cousido-Siah, A.,Fadel, F.,Golebiowski, A. (登録日: 2017-04-22, 公開日: 2018-03-28)

• 主引用文献: Mazur, M.,Olczak, J.,Olejniczak, S.,Koralewski, R.,Czestkowski, W.,Jedrzejczak, A.,Golab, J.,Dzwonek, K.,Dymek, B.,Sklepkiewicz, P.L.,Zagozdzon, A.,Noonan, T.,Mahboubi, K.,Conway, B.,Sheeler, R.,Beckett, P.,Hungerford, W.M.,Podjarny, A.,Mitschler, A.,Cousido-Siah, A.,Fadel, F.,Golebiowski, A.; Targeting Acidic Mammalian chitinase Is Effective in Animal Model of Asthma.; J. Med. Chem., 61:695-710, 2018; PubMed: 29283260; DOI: 10.1021/acs.jmedchem.7b01051

実験手法

X-RAY DIFFRACTION (1.447 Å)