5NPP

2.22A STRUCTURE OF THIOPHENE2 AND GSK945237 WITH S.AUREUS DNA GYRASE AND DNA

Summary for 5NPP

• Entry DOI: 10.2210/pdb5npp/pdb
• Descriptor: DNA gyrase subunit B,DNA gyrase subunit B,DNA gyrase subunit A, DNA (5'-D(*AP*GP*CP*CP*GP*TP*AP*GP*GP*TP*AP*CP*CP*TP*AP*CP*GP*GP*CP*T)-3'), MANGANESE (II) ION, ... (10 entities in total)
• Functional Keywords: type iia topoisomerase, antibacterial, inhibitor, isomerase
• Biological source: Staphylococcus aureus; More
• Cellular location: Cytoplasm : Q99XG5
• Total number of polymer chains: 6
• Total formula weight: 170663.15

Authors

Bax, B.D.,Chan, P.F.,Stavenger, R.A. (deposition date: 2017-04-18, release date: 2017-07-12)

• Primary citation: Chan, P.F.,Germe, T.,Bax, B.D.,Huang, J.,Thalji, R.K.,Bacque, E.,Checchia, A.,Chen, D.,Cui, H.,Ding, X.,Ingraham, K.,McCloskey, L.,Raha, K.,Srikannathasan, V.,Maxwell, A.,Stavenger, R.A.; Thiophene antibacterials that allosterically stabilize DNA-cleavage complexes with DNA gyrase.; Proc. Natl. Acad. Sci. U.S.A., 114:E4492-E4500, 2017; PubMed: 28507124; DOI: 10.1073/pnas.1700721114

Experimental method

X-RAY DIFFRACTION (2.22 Å)