5NDZ

Crystal structure of a thermostabilised human protease-activated receptor-2 (PAR2) in complex with AZ3451 at 3.6 angstrom resolution

Summary for 5NDZ

• Entry DOI: 10.2210/pdb5ndz/pdb
• Descriptor: Lysozyme,Proteinase-activated receptor 2,Soluble cytochrome b562,Proteinase-activated receptor 2, 2-(6-bromanyl-1,3-benzodioxol-5-yl)-~{N}-(4-cyanophenyl)-1-[(1~{S})-1-cyclohexylethyl]benzimidazole-5-carboxamide, SODIUM ION, ... (4 entities in total)
• Functional Keywords: membrane protein, gpcr, 7tm
• Biological source: Enterobacteria phage T4; More
• Cellular location: Cell membrane; Multi-pass membrane protein: P55085
• Total number of polymer chains: 1
• Total formula weight: 70153.35

Authors

Cheng, R.K.Y.,Fiez-Vandal, C.,Schlenker, O.,Edman, K.,Aggeler, B.,Brown, D.G.,Brown, G.,Cooke, R.M.,Dumelin, C.E.,Dore, A.S.,Geschwindner, S.,Grebner, C.,Hermansson, N.-O.,Jazayeri, A.,Johansson, P.,Leong, L.,Prihandoko, R.,Rappas, M.,Soutter, H.,Snijder, A.,Sundstrom, L.,Tehan, B.,Thornton, P.,Troast, D.,Wiggin, G.,Zhukov, A.,Marshall, F.H.,Dekker, N. (deposition date: 2017-03-09, release date: 2017-05-03, Last modification date: 2024-01-17)

• Primary citation: Cheng, R.K.Y.,Fiez-Vandal, C.,Schlenker, O.,Edman, K.,Aggeler, B.,Brown, D.G.,Brown, G.A.,Cooke, R.M.,Dumelin, C.E.,Dore, A.S.,Geschwindner, S.,Grebner, C.,Hermansson, N.O.,Jazayeri, A.,Johansson, P.,Leong, L.,Prihandoko, R.,Rappas, M.,Soutter, H.,Snijder, A.,Sundstrom, L.,Tehan, B.,Thornton, P.,Troast, D.,Wiggin, G.,Zhukov, A.,Marshall, F.H.,Dekker, N.; Structural insight into allosteric modulation of protease-activated receptor 2.; Nature, 545:112-115, 2017; PubMed: 28445455; DOI: 10.1038/nature22309

Experimental method

X-RAY DIFFRACTION (3.6 Å)