5NDV

Crystal structure of Paromomycin bound to the yeast 80S ribosome

This is a non-PDB format compatible entry.

Summary for 5NDV

• Entry DOI: 10.2210/pdb5ndv/pdb
• Descriptor: 25S ribosomal RNA, 60S ribosomal protein L8-A, 60S ribosomal protein L9-A, ... (83 entities in total)
• Functional Keywords: translation, ribosome, 40s, 60s, 80s, eukaryote, rna-protein complex, inhibitor, antibiotic, aminoglycoside, paromomycin
• Biological source: Saccharomyces cerevisiae (strain ATCC 204508 / S288c); More
• Cellular location: Cytoplasm : P17076 P05738 P41805 Q3E757 Q12690 P36105 P05748 P26784 P05740 P0CX49 P0CX82 P0CX23 Q02753 P05749 P0CX41 P04449 P04456 P05743 P0C2H6 P02406 P05747 P14120 P0C2H8 P38061 P05744 P87262 P0CX84 P05745 P49166 P49167 P0CX45 P04650 P0CX87 P0CX27 P0CX25 P32905 B3RHV0 P25443 P05750 P14126 P0CX35 P26783 P0CX37 P26786 P0CX39 O13516 Q08745 P0CX47 P48589 P05756 P10664 P39516 Q01855 P0CX51 P02407 P0CX55 P07280 P38701 P0C0V8 P0C0W1 P0CX29 P26321 P0CX31 Q3E792 P39939 P35997 Q3E7X9 P41057 P0CX33 P38011 P39015 P0CX37 Q02326 P05737; Ubiquitin: Cytoplasm . 60S ribosomal protein L40-A: Cytoplasm : P0CH08
• Total number of polymer chains: 156
• Total formula weight: 6227434.08

Authors

Prokhorova, I.,Djumagulov, M.,Urzhumtsev, A.,Yusupov, M.,Yusupova, G. (deposition date: 2017-03-09, release date: 2017-12-13, Last modification date: 2017-12-27)

• Primary citation: Prokhorova, I.,Altman, R.B.,Djumagulov, M.,Shrestha, J.P.,Urzhumtsev, A.,Ferguson, A.,Chang, C.T.,Yusupov, M.,Blanchard, S.C.,Yusupova, G.; Aminoglycoside interactions and impacts on the eukaryotic ribosome.; Proc. Natl. Acad. Sci. U.S.A., 114:E10899-E10908, 2017; PubMed: 29208708; DOI: 10.1073/pnas.1715501114

Experimental method

X-RAY DIFFRACTION (3.3 Å)