5NCZ

mPI3Kd IN COMPLEX WITH inh1

Summary for 5NCZ

Entry DOI	10.2210/pdb5ncz/pdb
Descriptor	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform, 1,2-ETHANEDIOL, 4-azanyl-6-[[(1~{S})-1-[6-[3-[(dimethylamino)methyl]phenyl]-3-methyl-5-oxidanylidene-[1,3]thiazolo[3,2-a]pyridin-7-yl]ethyl]amino]pyrimidine-5-carbonitrile, ... (4 entities in total)
Functional Keywords	mi3kd, inhibitor, complex pi3k, transferase
Biological source	Mus musculus (Mouse)
Cellular location	Cytoplasm : O35904
Total number of polymer chains	1
Total formula weight	108080.05
Authors	Petersen, J. (deposition date: 2017-03-06, release date: 2017-06-21, Last modification date: 2017-07-05)
Primary citation	Perry, M.W.D.,Bjorhall, K.,Bonn, B.,Carlsson, J.,Chen, Y.,Eriksson, A.,Fredlund, L.,Hao, H.,Holden, N.S.,Karabelas, K.,Lindmark, H.,Liu, F.,Pemberton, N.,Petersen, J.,Rodrigo Blomqvist, S.,Smith, R.W.,Svensson, T.,Terstiege, I.,Tyrchan, C.,Yang, W.,Zhao, S.,Oster, L. Design and Synthesis of Soluble and Cell-Permeable PI3K delta Inhibitors for Long-Acting Inhaled Administration. J. Med. Chem., 60:5057-5071, 2017 Cited by PubMed: 28520415 DOI: 10.1021/acs.jmedchem.7b00401 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.94 Å)

Structure validation