5MYA

Homodimerization of Tie2 Fibronectin-like domains 1-3 in space group C2

Summary for 5MYA

Entry DOI	10.2210/pdb5mya/pdb
Descriptor	Angiopoietin-1 receptor, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, alpha-D-mannopyranose-(1-3)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (6 entities in total)
Functional Keywords	receptor, fibronectin-like domains, dimerization, homotypic interactions, signaling protein
Biological source	Homo sapiens (Human)
Cellular location	Cell membrane; Single-pass type I membrane protein: Q02763
Total number of polymer chains	2
Total formula weight	77811.08
Authors	Leppanen, V.-M.,Saharinen, P.,Alitalo, K. (deposition date: 2017-01-26, release date: 2017-04-26, Last modification date: 2020-07-29)
Primary citation	Leppanen, V.M.,Saharinen, P.,Alitalo, K. Structural basis of Tie2 activation and Tie2/Tie1 heterodimerization. Proc. Natl. Acad. Sci. U.S.A., 114:4376-4381, 2017 Cited by PubMed: 28396439 DOI: 10.1073/pnas.1616166114 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.9 Å)

Structure validation