5MPK
Crystal structure of CREBBP bromodomain complexed with DK19
Summary for 5MPK
| Entry DOI | 10.2210/pdb5mpk/pdb |
| Descriptor | CREB-binding protein, ~{N}-(5-ethanoyl-2-ethoxy-phenyl)-3-(2~{H}-1,2,3,4-tetrazol-5-yl)-5-(1,3-thiazol-4-yl)benzamide (3 entities in total) |
| Functional Keywords | crebbp bromodomain, inhibitor, transcription |
| Biological source | Homo sapiens (Human) |
| Total number of polymer chains | 2 |
| Total formula weight | 29315.64 |
| Authors | Zhu, J.,Caflisch, A. (deposition date: 2016-12-16, release date: 2018-01-17, Last modification date: 2019-10-16) |
| Primary citation | Zhu, J.,Dong, J.,Batiste, L.,Unzue, A.,Dolbois, A.,Pascanu, V.,Sledz, P.,Nevado, C.,Caflisch, A. Binding Motifs in the CBP Bromodomain: An Analysis of 20 Crystal Structures of Complexes with Small Molecules. ACS Med Chem Lett, 9:929-934, 2018 Cited by PubMed: 30258543DOI: 10.1021/acsmedchemlett.8b00286 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (1.9 Å) |
Structure validation
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