5MAH

Crystal structure of MELK in complex with an inhibitor

5MAH の概要

分子名称Maternal embryonic leucine zipper kinase, ~{N}-methyl-4-[[4-[[3-[methyl(methylsulfonyl)amino]pyrazin-2-yl]methylamino]-5-(trifluoromethyl)pyrimidin-2-yl]amino]benzamide, GLYCEROL, ... (6 entities in total)
機能のキーワードkinase, inhibitor, complex, transferase
由来する生物種Homo sapiens (Human)
細胞内の位置Cell membrane ; Peripheral membrane protein  Q14680
ポリマー鎖数1
分子量合計40904.56
構造登録者
Canevari, G.,Re Depaolini, S.,Casale, E.,Felder, E.,Kuster, B.,Heinzlmeir, S. (登録日: 2016-11-03, 公開日: 2017-12-06, 最終更新日: 2017-12-13)
主引用文献
Klaeger, S.,Heinzlmeir, S.,Wilhelm, M.,Polzer, H.,Vick, B.,Koenig, P.A.,Reinecke, M.,Ruprecht, B.,Petzoldt, S.,Meng, C.,Zecha, J.,Reiter, K.,Qiao, H.,Helm, D.,Koch, H.,Schoof, M.,Canevari, G.,Casale, E.,Depaolini, S.R.,Feuchtinger, A.,Wu, Z.,Schmidt, T.,Rueckert, L.,Becker, W.,Huenges, J.,Garz, A.K.,Gohlke, B.O.,Zolg, D.P.,Kayser, G.,Vooder, T.,Preissner, R.,Hahne, H.,Tonisson, N.,Kramer, K.,Gotze, K.,Bassermann, F.,Schlegl, J.,Ehrlich, H.C.,Aiche, S.,Walch, A.,Greif, P.A.,Schneider, S.,Felder, E.R.,Ruland, J.,Medard, G.,Jeremias, I.,Spiekermann, K.,Kuster, B.
The target landscape of clinical kinase drugs.
Science, 358:-, 2017
PubMed: 29191878 (主引用文献が同じPDBエントリー)
DOI: 10.1126/science.aan4368
MImport into Mendeley
実験手法
X-RAY DIFFRACTION (2 Å)
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構造検証レポート

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.239102.1%2.5%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
検証レポート(詳細版)をダウンロード