5M7G

Tubulin-MTD147 complex

Summary for 5M7G

• Entry DOI: 10.2210/pdb5m7g/pdb
• Related: 4O2B 5M7E
• Descriptor: Tubulin alpha-1B chain, GUANOSINE-5'-DIPHOSPHATE, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, ... (13 entities in total)
• Functional Keywords: cell cycle, tubulin fold, cytoskeleton, microtubule
• Biological source: Rattus norvegicus (Norway Rat); More
• Cellular location: Cytoplasm, cytoskeleton: P81947 Q6B856; Golgi apparatus : P63043
• Total number of polymer chains: 6
• Total formula weight: 265589.44

Authors

Bohnacker, T.,Prota, A.E.,Steinmetz, M.O.,Wymann, M.P. (deposition date: 2016-10-27, release date: 2017-02-22, Last modification date: 2024-01-17)

• Primary citation: Bohnacker, T.,Prota, A.E.,Beaufils, F.,Burke, J.E.,Melone, A.,Inglis, A.J.,Rageot, D.,Sele, A.M.,Cmiljanovic, V.,Cmiljanovic, N.,Bargsten, K.,Aher, A.,Akhmanova, A.,Diaz, J.F.,Fabbro, D.,Zvelebil, M.,Williams, R.L.,Steinmetz, M.O.,Wymann, M.P.; Deconvolution of Buparlisib's mechanism of action defines specific PI3K and tubulin inhibitors for therapeutic intervention.; Nat Commun, 8:14683-14683, 2017; PubMed: 28276440; DOI: 10.1038/ncomms14683

Experimental method

X-RAY DIFFRACTION (2.248 Å)