5M7F

Human porphobilinogen deaminase in complex with DPM cofactor

Summary for 5M7F

• Entry DOI: 10.2210/pdb5m7f/pdb
• Descriptor: Porphobilinogen deaminase, 3-[5-{[3-(2-carboxyethyl)-4-(carboxymethyl)-5-methyl-1H-pyrrol-2-yl]methyl}-4-(carboxymethyl)-1H-pyrrol-3-yl]propanoic acid, SULFATE ION, ... (4 entities in total)
• Functional Keywords: porphobilinogen deaminase, heme biosynthesis, porphyria, hmbs, transferase
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 2
• Total formula weight: 81987.29

Authors

Pluta, P.,Millet, O.,Roversi, P.,Rojas, A.L.,Gu, S. (deposition date: 2016-10-27, release date: 2017-11-15, Last modification date: 2024-01-17)

• Primary citation: Pluta, P.,Roversi, P.,Bernardo-Seisdedos, G.,Rojas, A.L.,Cooper, J.B.,Gu, S.,Pickersgill, R.W.,Millet, O.; Structural basis of pyrrole polymerization in human porphobilinogen deaminase.; Biochim Biophys Acta Gen Subj, 1862:1948-1955, 2018; PubMed: 29908816; DOI: 10.1016/j.bbagen.2018.06.013

Experimental method

X-RAY DIFFRACTION (2.78 Å)