5M51

Nek2 bound to arylaminopurine compound 8

Summary for 5M51

Entry DOI	10.2210/pdb5m51/pdb
Descriptor	Serine/threonine-protein kinase Nek2, 3-[[6-(cyclohexylmethoxy)-9~{H}-purin-2-yl]amino]benzamide (3 entities in total)
Functional Keywords	protein kinase, inhibitor, centrosome separation, transferase-inhibitor complex, transferase/inhibitor
Biological source	Homo sapiens (Human)
Cellular location	Isoform 1: Nucleus. Isoform 2: Cytoplasm. Isoform 4: Nucleus: P51955
Total number of polymer chains	1
Total formula weight	33028.90
Authors	Bayliss, R.,Yeoh, S. (deposition date: 2016-10-20, release date: 2016-11-09, Last modification date: 2024-01-17)
Primary citation	Coxon, C.R.,Wong, C.,Bayliss, R.,Boxall, K.,Carr, K.H.,Fry, A.M.,Hardcastle, I.R.,Matheson, C.J.,Newell, D.R.,Sivaprakasam, M.,Thomas, H.,Turner, D.,Yeoh, S.,Wang, L.Z.,Griffin, R.J.,Golding, B.T.,Cano, C. Structure-guided design of purine-based probes for selective Nek2 inhibition. Oncotarget, 8:19089-19124, 2017 Cited by PubMed: 27833088 DOI: 10.18632/oncotarget.13249 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.899 Å)

Structure validation