5LVP
Human PDK1 Kinase Domain in Complex with an HM-Peptide Bound to the PIF-Pocket
Summary for 5LVP
Entry DOI | 10.2210/pdb5lvp/pdb |
Descriptor | 3-phosphoinositide-dependent protein kinase 1, hydrophobic-motif peptide of PKB/Akt, ADENOSINE-5'-TRIPHOSPHATE, ... (5 entities in total) |
Functional Keywords | protein kinase, allosteric regulation, small compounds, pif-pocket, transferase |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 8 |
Total formula weight | 149715.93 |
Authors | Schulze, J.O.,Saladino, G.,Busschots, K.,Neimanis, S.,Suess, E.,Odadzic, D.,Zeuzem, S.,Hindie, V.,Herbrand, A.K.,Lisa, M.N.,Alzari, P.M.,Gervasio, F.L.,Biondi, R.M. (deposition date: 2016-09-14, release date: 2016-10-19, Last modification date: 2019-10-16) |
Primary citation | Schulze, J.O.,Saladino, G.,Busschots, K.,Neimanis, S.,Su, E.,Odadzic, D.,Zeuzem, S.,Hindie, V.,Herbrand, A.K.,Lisa, M.N.,Alzari, P.M.,Gervasio, F.L.,Biondi, R.M. Bidirectional Allosteric Communication between the ATP-Binding Site and the Regulatory PIF Pocket in PDK1 Protein Kinase. Cell Chem Biol, 23:1193-1205, 2016 Cited by PubMed: 27693059DOI: 10.1016/j.chembiol.2016.06.017 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.5 Å) |
Structure validation
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