5LVO

Human PDK1 Kinase Domain in Complex with Allosteric Compound PSE10 Bound to the PIF-Pocket

Summary for 5LVO

Entry DOI	10.2210/pdb5lvo/pdb
Descriptor	3-phosphoinositide-dependent protein kinase 1, ADENOSINE-5'-TRIPHOSPHATE, 2-oxidanylidenepropyl ~{N}-(2-chloranyl-6-fluoranyl-phenyl)carbonyl-~{N}'-(4-chlorophenyl)carbamimidothioate, ... (7 entities in total)
Functional Keywords	protein kinase, allosteric regulation, small compounds, pif-pocket, transferase
Biological source	Homo sapiens (Human)
Total number of polymer chains	1
Total formula weight	36564.83
Authors	Schulze, J.O.,Saladino, G.,Busschots, K.,Neimanis, S.,Suess, E.,Odadzic, D.,Zeuzem, S.,Hindie, V.,Herbrand, A.K.,Lisa, M.N.,Alzari, P.M.,Gervasio, F.L.,Biondi, R.M. (deposition date: 2016-09-14, release date: 2016-10-19, Last modification date: 2024-01-17)
Primary citation	Schulze, J.O.,Saladino, G.,Busschots, K.,Neimanis, S.,Su, E.,Odadzic, D.,Zeuzem, S.,Hindie, V.,Herbrand, A.K.,Lisa, M.N.,Alzari, P.M.,Gervasio, F.L.,Biondi, R.M. Bidirectional Allosteric Communication between the ATP-Binding Site and the Regulatory PIF Pocket in PDK1 Protein Kinase. Cell Chem Biol, 23:1193-1205, 2016 Cited by PubMed: 27693059 DOI: 10.1016/j.chembiol.2016.06.017 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.09 Å)

Structure validation