5LOV

DZ-2384 tubulin complex

Summary for 5LOV

• Entry DOI: 10.2210/pdb5lov/pdb
• Related: 4I55 5J2T
• Descriptor: Tubulin alpha-1B chain, DZ 2384, PHOSPHOMETHYLPHOSPHONIC ACID ADENYLATE ESTER, ... (12 entities in total)
• Functional Keywords: cell cycle, tubulin fold, cytoskeleton, microtubule
• Biological source: Rattus norvegicus (Norway Rat); More
• Cellular location: Cytoplasm, cytoskeleton: P81947 Q6B856; Golgi apparatus : P63043
• Total number of polymer chains: 6
• Total formula weight: 265023.20

Authors

Prota, A.E.,Steinmetz, M.O.,Shore, G.C.,Brouhard, G.,Roulston, A. (deposition date: 2016-08-10, release date: 2016-11-30, Last modification date: 2024-01-10)

• Primary citation: Wieczorek, M.,Tcherkezian, J.,Bernier, C.,Prota, A.E.,Chaaban, S.,Rolland, Y.,Godbout, C.,Hancock, M.A.,Arezzo, J.C.,Ocal, O.,Rocha, C.,Olieric, N.,Hall, A.,Ding, H.,Bramoulle, A.,Annis, M.G.,Zogopoulos, G.,Harran, P.G.,Wilkie, T.M.,Brekken, R.A.,Siegel, P.M.,Steinmetz, M.O.,Shore, G.C.,Brouhard, G.J.,Roulston, A.; The synthetic diazonamide DZ-2384 has distinct effects on microtubule curvature and dynamics without neurotoxicity.; Sci Transl Med, 8:365ra159-365ra159, 2016; PubMed: 27856798; DOI: 10.1126/scitranslmed.aag1093

Experimental method

X-RAY DIFFRACTION (2.4 Å)