5LGA

Structural analysis and biological activities of BXL0124, a Gemini analog of Vitamin D

Summary for 5LGA

Entry DOI	10.2210/pdb5lga/pdb
Descriptor	Vitamin D3 receptor A, SRC-2, (1~{R},3~{S},5~{Z})-5-[2-[(1~{R},3~{a}~{S},7~{a}~{R})-7~{a}-methyl-1-[(6~{R})-1,1,1-tris(fluoranyl)-10-methyl-2,10-bis(oxidanyl)-2-(trifluoromethyl)undeca-3,8-diyn-6-yl]-2,3,3~{a},5,6,7-hexahydro-1~{H}-inden-4-ylidene]ethylidene]-4-methylidene-cyclohexane-1,3-diol, ... (4 entities in total)
Functional Keywords	vitamin d nuclear receptor, agonist, gemini, transcription
Biological source	Danio rerio (Zebrafish) More
Cellular location	Nucleus: Q9PTN2
Total number of polymer chains	2
Total formula weight	36099.06
Authors	Belorusova, A.Y.,Rochel, N. (deposition date: 2016-07-06, release date: 2016-10-19, Last modification date: 2024-01-10)
Primary citation	Belorusova, A.Y.,Suh, N.,Lee, H.J.,So, J.Y.,Maehr, H.,Rochel, N. Structural analysis and biological activities of BXL0124, a gemini analog of vitamin D. J. Steroid Biochem. Mol. Biol., 173:69-74, 2017 Cited by PubMed: 27650654 DOI: 10.1016/j.jsbmb.2016.09.015 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.5 Å)

Structure validation