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5L5U

Yeast 20S proteasome with human beta5i (1-138; V31M) and human beta6 (97-111; 118-133) in complex with epoxyketone inhibitor 17

Summary for 5L5U
Entry DOI10.2210/pdb5l5u/pdb
Related5CZ4
Related PRD IDPRD_000991
DescriptorProteasome subunit alpha type-2, Proteasome subunit beta type-4, Proteasome subunit beta type-8,Proteasome subunit beta type-5, ... (18 entities in total)
Functional Keywordshydrolase-hydrolase inhibitor complex, proteasome, mutant, inhibitor, binding analysis, hydrolase/hydrolase inhibitor
Biological sourceHomo sapiens (Human)
More
Cellular locationCytoplasm: P23639 P22141 P30656 P23724 P30657 P38624 P23638 P40303 P32379 P40302 P21242 P21243 P25043 P25451
Total number of polymer chains28
Total formula weight734056.38
Authors
Groll, M.,Huber, E.M. (deposition date: 2016-05-28, release date: 2016-11-09, Last modification date: 2024-01-10)
Primary citationHuber, E.M.,Heinemeyer, W.,de Bruin, G.,Overkleeft, H.S.,Groll, M.
A humanized yeast proteasome identifies unique binding modes of inhibitors for the immunosubunit beta 5i.
EMBO J., 35:2602-2613, 2016
Cited by
PubMed: 27789522
DOI: 10.15252/embj.201695222
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.6 Å)
Structure validation

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