5L3B

Human LSD1/CoREST: LSD1 D556G mutation

Summary for 5L3B

• Entry DOI: 10.2210/pdb5l3b/pdb
• Descriptor: Lysine-specific histone demethylase 1A, REST corepressor 1, FLAVIN-ADENINE DINUCLEOTIDE (3 entities in total)
• Functional Keywords: oxidoreductase-repressor complex, histone demethylase, chromatin, flavin, fad, oxidoreductase/repressor
• Biological source: Homo sapiens (Human); More
• Cellular location: Nucleus : O60341 Q9UKL0
• Total number of polymer chains: 2
• Total formula weight: 146840.93

Authors

Pilotto, S.,Speranzini, V.,Marabelli, C. (deposition date: 2016-04-06, release date: 2016-05-04, Last modification date: 2024-01-10)

• Primary citation: Pilotto, S.,Speranzini, V.,Marabelli, C.,Rusconi, F.,Toffolo, E.,Grillo, B.,Battaglioli, E.,Mattevi, A.; LSD1/KDM1A mutations associated to a newly described form of intellectual disability impair demethylase activity and binding to transcription factors.; Hum.Mol.Genet., 25:2578-2587, 2016; PubMed: 27094131; DOI: 10.1093/hmg/ddw120

Experimental method

X-RAY DIFFRACTION (3.3 Å)