5KZY

Crystal structure of the xenopus Smoothened cysteine-rich domain (CRD) in complex with cyclopamine

Summary for 5KZY

• Entry DOI: 10.2210/pdb5kzy/pdb
• Related: 5KZV
• Descriptor: Smoothened, Cyclopamine (3 entities in total)
• Functional Keywords: hedgehog signaling, gpcr, cysteine-rich domain, sterol, signaling protein
• Biological source: Xenopus laevis (African clawed frog)
• Total number of polymer chains: 2
• Total formula weight: 27628.01

Authors

Huang, P.,Kim, Y.,Salic, A. (deposition date: 2016-07-25, release date: 2016-08-17, Last modification date: 2023-10-04)

• Primary citation: Huang, P.,Nedelcu, D.,Watanabe, M.,Jao, C.,Kim, Y.,Liu, J.,Salic, A.; Cellular Cholesterol Directly Activates Smoothened in Hedgehog Signaling.; Cell, 166:1176-1187.e14, 2016; PubMed: 27545348; DOI: 10.1016/j.cell.2016.08.003

Experimental method

X-RAY DIFFRACTION (2.484 Å)