5KWY

Structure of human NPC1 middle lumenal domain bound to NPC2

Summary for 5KWY

• Entry DOI: 10.2210/pdb5kwy/pdb
• Descriptor: Niemann-Pick C1 protein, Epididymal secretory protein E1, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... (5 entities in total)
• Functional Keywords: human protein complex, npc1, npc2, transport protein
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 4
• Total formula weight: 87614.39

Authors

Li, X. (deposition date: 2016-07-19, release date: 2016-08-24, Last modification date: 2023-10-04)

• Primary citation: Li, X.,Saha, P.,Li, J.,Blobel, G.,Pfeffer, S.R.; Clues to the mechanism of cholesterol transfer from the structure of NPC1 middle lumenal domain bound to NPC2.; Proc.Natl.Acad.Sci.USA, 113:10079-10084, 2016; PubMed: 27551080; DOI: 10.1073/pnas.1611956113

Experimental method

X-RAY DIFFRACTION (2.405 Å)