5KUP

Bruton's tyrosine kinase (BTK) with pyridazinone compound 9

Summary for 5KUP

Entry DOI	10.2210/pdb5kup/pdb
Descriptor	Tyrosine-protein kinase BTK, SULFATE ION, GLYCEROL, ... (6 entities in total)
Functional Keywords	protein kinase, inhibitor, non covalent, transferase-transferase inhibitor complex, transferase/transferase inhibitor
Biological source	Homo sapiens (Human)
Cellular location	Cytoplasm: Q06187
Total number of polymer chains	1
Total formula weight	32812.60
Authors	Eigenbrot, C.,Yu, C. (deposition date: 2016-07-13, release date: 2016-09-14, Last modification date: 2023-10-04)
Primary citation	Johnson, A.R.,Kohli, P.B.,Katewa, A.,Gogol, E.,Belmont, L.D.,Choy, R.,Penuel, E.,Burton, L.,Eigenbrot, C.,Yu, C.,Ortwine, D.F.,Bowman, K.,Franke, Y.,Tam, C.,Estevez, A.,Mortara, K.,Wu, J.,Li, H.,Lin, M.,Bergeron, P.,Crawford, J.J.,Young, W.B. Battling Btk Mutants With Noncovalent Inhibitors That Overcome Cys481 and Thr474 Mutations. Acs Chem.Biol., 11:2897-2907, 2016 Cited by PubMed: 27571029 DOI: 10.1021/acschembio.6b00480 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.389 Å)

Structure validation