5KQ5

AMPK bound to allosteric activator

5KQ5 の概要

• エントリーDOI: 10.2210/pdb5kq5/pdb
• 分子名称: 5'-AMP-activated protein kinase catalytic subunit alpha-1, 5'-AMP-activated protein kinase subunit beta-1, 5'-AMP-activated protein kinase subunit gamma-1, ... (9 entities in total)
• 機能のキーワード: kinase allosteric activator, transferase
• 由来する生物種: Rattus norvegicus (Rat); 詳細
• 細胞内の位置: Cytoplasm : P54645
• タンパク質・核酸の鎖数: 3
• 化学式量合計: 120426.34

構造登録者

Calabrese, M.F.,Kurumbail, R.G. (登録日: 2016-07-05, 公開日: 2016-08-17, 最終更新日: 2023-10-04)

• 主引用文献: Cameron, K.O.,Kung, D.W.,Kalgutkar, A.S.,Kurumbail, R.G.,Miller, R.,Salatto, C.T.,Ward, J.,Withka, J.M.,Bhattacharya, S.K.,Boehm, M.,Borzilleri, K.A.,Brown, J.A.,Calabrese, M.,Caspers, N.L.,Cokorinos, E.,Conn, E.L.,Dowling, M.S.,Edmonds, D.J.,Eng, H.,Fernando, D.P.,Frisbie, R.,Hepworth, D.,Landro, J.,Mao, Y.,Rajamohan, F.,Reyes, A.R.,Rose, C.R.,Ryder, T.,Shavnya, A.,Smith, A.C.,Tu, M.,Wolford, A.C.,Xiao, J.; Discovery and Preclinical Characterization of 6-Chloro-5-[4-(1-hydroxycyclobutyl)phenyl]-1H-indole-3-carboxylic Acid (PF-06409577), a Direct Activator of Adenosine Monophosphate-activated Protein Kinase (AMPK), for the Potential Treatment of Diabetic Nephropathy.; J.Med.Chem., 59:8068-8081, 2016; PubMed: 27490827; DOI: 10.1021/acs.jmedchem.6b00866

実験手法

X-RAY DIFFRACTION (3.41 Å)