5K13

Crystal structure of the RAR alpha ligand-binding domain in complex with an antagonist

Summary for 5K13

Entry DOI	10.2210/pdb5k13/pdb
Descriptor	Retinoic acid receptor alpha, 4-{5-(3-tert-butylphenyl)-1-[4-(methylsulfonyl)phenyl]-1H-pyrazol-3-yl}benzoic acid (3 entities in total)
Functional Keywords	nhr ligand-binding domain, antagonist, transcription
Biological source	Homo sapiens (Human)
Cellular location	Nucleus: P10276
Total number of polymer chains	1
Total formula weight	28163.69
Authors	Wang, Y.,Stout, S.L. (deposition date: 2016-05-17, release date: 2016-06-22, Last modification date: 2023-09-27)
Primary citation	Hughes, N.E.,Bleisch, T.J.,Jones, S.A.,Richardson, T.I.,Doti, R.A.,Wang, Y.,Stout, S.L.,Durst, G.L.,Chambers, M.G.,Oskins, J.L.,Lin, C.,Adams, L.A.,Page, T.J.,Barr, R.J.,Zink, R.W.,Osborne, H.,Montrose-Rafizadeh, C.,Norman, B.H. Identification of potent and selective retinoic acid receptor gamma (RAR gamma ) antagonists for the treatment of osteoarthritis pain using structure based drug design. Bioorg.Med.Chem.Lett., 26:3274-3277, 2016 Cited by PubMed: 27261179 DOI: 10.1016/j.bmcl.2016.05.056 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.85 Å)

Structure validation