5JVW

Crystal structure of mithramycin analogue MTM SA-Trp in complex with a 10-mer DNA AGAGGCCTCT.

Summary for 5JVW

• Entry DOI: 10.2210/pdb5jvw/pdb
• Related: 5JVT 5JW0 5JW2
• Descriptor: DNA (5'-D(*AP*GP*AP*GP*GP*CP*CP*TP*CP*T)-3'), ZINC ION, SODIUM ION, ... (5 entities in total)
• Functional Keywords: anti-cancer agent, ewing sarcoma, transcription factor, minor groove, dna binding, dna-antibiotic complex, dna/antibiotic
• Biological source: synthetic construct
• Total number of polymer chains: 4
• Total formula weight: 18100.48

Authors

Hou, C.,Rohr, J.,Tsodikov, O.V. (deposition date: 2016-05-11, release date: 2016-09-14, Last modification date: 2024-03-06)

• Primary citation: Hou, C.,Weidenbach, S.,Cano, K.E.,Wang, Z.,Mitra, P.,Ivanov, D.N.,Rohr, J.,Tsodikov, O.V.; Structures of mithramycin analogues bound to DNA and implications for targeting transcription factor FLI1.; Nucleic Acids Res., 44:8990-9004, 2016; PubMed: 27587584; DOI: 10.1093/nar/gkw761

Experimental method

X-RAY DIFFRACTION (2 Å)